Molecular Mechanisms of Intracellular Delivery of Nanoparticles Monitored by an Enzyme-Induced Proximity Labeling

Molecular Mechanisms of Intracellular Delivery of Nanoparticles Monitored by an Enzyme-Induced Proximity Labeling

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Highlights Novel enzyme-induced proximity labeling technology in nanoparticles (nano-EPL).Nano-EPL Insert Vent enables dynamic molecular mapping of the intracellular delivery of nanoparticles in macrophages.Nano-EPL enables the elucidation of a comprehensive phagosome-centered timeline Plant Proteins during the vesicular transportation of nanoparticles, revealing distinct organelle engagement and its differential impact on drug delivery efficiency.